Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31709
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    標題: Constituents from the leaves of Clausena lansium and their anti-inflammatory activity
    作者: Shen, De-Yang
    Kuo, Ping-Chung
    Huang, Shiow-Chyn
    Hwang, Tsong-Long
    Chan, Yu-Yi
    Shieh, Po-Chuen
    Ngan, Nguyen Thi
    Thang, Tran Dinh
    Wu, Tian-Shung
    貢獻者: Natl Cheng Kung Univ, Coll Med, Sch Pharm,Natl Cheng Kung Univ Hosp
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chang Gung Univ, Coll Med, Grad Inst Nat Prod
    Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Res Ctr Chinese Herbal Med
    Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol
    Chang Gung Mem Hosp, Dept Anesthesiol
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Tajen Univ, Dept Pharm
    Vinh Univ, Dept Chem
    關鍵字: Clausenalansamide
    Electronic circular dichroism
    Single-crystal X-ray diffraction analysis
    Anti-inflammatory
    Superoxide anion generation
    日期: 2017-01
    上傳時間: 2018-11-30 15:53:45 (UTC+8)
    出版者: Springer Japan Kk
    摘要: Five new acyclic amides, clausenalansamides C-G (1-5), clausenaline G (6) and (+/-)-5-(4-methylphenyl)-gamma-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1-5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 +/- 0.3 and 6.8 +/- 1.1 mu M, respectively.
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