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    標題: Antiproliferative effect of sweet orange peel and its bioactive compounds against human hepatoma cells, in vitro and in vivo
    作者: Chu, Chin-Chen
    Chen, Shih-Ying
    Chyau, Charng-Cherng
    Duh, Pin-Der
    貢獻者: Chi Mei Med Ctr, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Hungkuang Univ, Res Inst Biotechnol
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    關鍵字: Sweet orange peel
    Nobiletin
    Tangeretin
    Human hepatomacellular carcinoma (HCC)
    HepG2 cells
    Reactive oxygen species
    Apoptosis
    日期: 2017-06
    上傳時間: 2018-11-30 15:53:19 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: The ethyl acetate extracts from sweet orange peel (EESP) and its bioactive compounds against human hepatoma cells, in vitro and in vivo, is investigated. EESP (50-500 mu g/ml) exhibits significant cytotoxicity on HepG2 cells. This antiproliferative action is partly attributable to cell cycle arrest in the G(0)/G(1) phase and apoptosis induction. EESP induces apoptosis through an increase in the Bax/Bcl-2 ratio, the down-regulation of mitochondrial membrane potential and the up-regulation of caspase-3. Excessive ROS generated by EESP contributes to apoptosis of HepG2 cells. According to the HPLC-DAD and HPLC-MS/MS analysis, nobiletin, tangeretin and another twelve compounds were present in EESP, which may account for its antiproliferative effect. When HepG2 cells are grown as xenografts in nude mice, the oral administration of EESP induces a significant decrease in tumor growth. Collectively, these results suggest that EESP could be a potential useful source for the future application of EESP in liver cancer therapy. (C) 2017 Elsevier Ltd. All rights reserved.
    關聯: Journal of Functional Foods, v.33, pp.363-375
    Appears in Collections:[ 食品科技系 ] 期刊論文
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