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| 標題: | Naloxone prolongs cutaneous nociceptive block by lidocaine in rats |
| 作者: | Chen, Yu-Wen
Shieh, Ja-Ping
Liu, Kuo-Sheng
Wang, Jhi-Joung
Hung, Ching-Hsia |
| 貢獻者: | Chi Mei Med Ctr, Dept Med Res
China Med Univ, Coll Hlth Care, Dept Phys Therapy
Chi Mei Med Ctr, Dept Anesthesiol
Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
Chia Nan Univ Pharm & Sci, Dept Pharm
Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy
Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci |
| 關鍵字: | coadministration
infiltrative cutaneous analgesia
lidocaine
naloxone
subcutaneous injection |
| 日期: | 2017-12 |
| 上傳時間: | 2018-11-30 15:51:38 (UTC+8) |
| 出版者: | Wiley |
| 摘要: | We aimed to investigate the local anesthetic properties of naloxone alone or as an adjunct for the local anesthetic lidocaine. After the block of the cutaneous trunci muscle reflex (CTMR) with drugsdelivery by subcutaneous infiltration, cutaneous nociceptive block was tested on the rats? backs. We demonstrated that naloxone, as well as lidocaine, elicited cutaneous analgesia dose-dependently. The relative potency in inducing cutaneous analgesia was lidocaine [22.6 (20.1 - 25.4) mol/kg] > naloxone [43.2 (40.3 - 46.4) mol/kg] (P<0.05). On an equianesthetic basis [50% effective dose (ED50), ED25, and ED75], naloxone displayed a greater duration of cutaneous analgesic action than lidocaine (P<0.01). Coadministration of lidocaine (ED95 or ED50) and ineffective-dose naloxone (13.3mol/kg) intensifies sensory block (P<0.01) with prolonged duration of action (P<0.001) compared with lidocaine (ED95 or ED50) alone or naloxone (13.3mol/kg) alone on infiltrative cutaneous analgesia. The preclinical data showed that naloxone is less potent than lidocaine as an infiltrative anesthetic, but its analgesic duration was longer than that of lidocaine. Furthermore, naloxone prolongs lidocaine analgesia, acting synergistically for nociceptive block. |
| 關聯: | Fundamental & Clinical Pharmacology, v.31, n.6, pp.636-642 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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