Naloxone prolongs cutaneous nociceptive block by lidocaine in rats

doi:10.1111/fcp.12302

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Title:	Naloxone prolongs cutaneous nociceptive block by lidocaine in rats
Authors:	Chen, Yu-Wen Shieh, Ja-Ping Liu, Kuo-Sheng Wang, Jhi-Joung Hung, Ching-Hsia
Contributors:	Chi Mei Med Ctr, Dept Med Res China Med Univ, Coll Hlth Care, Dept Phys Therapy Chi Mei Med Ctr, Dept Anesthesiol Southern Taiwan Univ Sci & Technol, Ctr Gen Educ Chia Nan Univ Pharm & Sci, Dept Pharm Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
Keywords:	coadministration infiltrative cutaneous analgesia lidocaine naloxone subcutaneous injection
Date:	2017-12
Issue Date:	2018-11-30 15:51:38 (UTC+8)
Publisher:	Wiley
Abstract:	We aimed to investigate the local anesthetic properties of naloxone alone or as an adjunct for the local anesthetic lidocaine. After the block of the cutaneous trunci muscle reflex (CTMR) with drugsdelivery by subcutaneous infiltration, cutaneous nociceptive block was tested on the rats? backs. We demonstrated that naloxone, as well as lidocaine, elicited cutaneous analgesia dose-dependently. The relative potency in inducing cutaneous analgesia was lidocaine [22.6 (20.1 - 25.4) mol/kg] > naloxone [43.2 (40.3 - 46.4) mol/kg] (P<0.05). On an equianesthetic basis [50% effective dose (ED50), ED25, and ED75], naloxone displayed a greater duration of cutaneous analgesic action than lidocaine (P<0.01). Coadministration of lidocaine (ED95 or ED50) and ineffective-dose naloxone (13.3mol/kg) intensifies sensory block (P<0.01) with prolonged duration of action (P<0.001) compared with lidocaine (ED95 or ED50) alone or naloxone (13.3mol/kg) alone on infiltrative cutaneous analgesia. The preclinical data showed that naloxone is less potent than lidocaine as an infiltrative anesthetic, but its analgesic duration was longer than that of lidocaine. Furthermore, naloxone prolongs lidocaine analgesia, acting synergistically for nociceptive block.
Relation:	Fundamental & Clinical Pharmacology, v.31, n.6, pp.636-642
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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