Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents

doi:10.1016/j.fct.2017.09.010

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標題:	Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents
作者:	Teng, Hui Lin, Qiyang Li, Kang Yuan, Benyao Song, Hongbo Peng, Hongquan Yi, Lunzhao Wei, Ming-Chi Yang, Yu-Chiao Battino, Maurizio Cespedes Acuna, Carlos L. Chen, Lei Xiao, Jianbo
貢獻者:	Fujian Agr & Forestry Univ, Coll Food Sci Kiang Wu Hosp, Macau Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat Kaohsiung Med Univ, Dept & Grad Inst Pharmacol Univ Europea Atlantico, Ctr Nutr & Hlth Univ Europea, Univ Nutr & Hlth, Dept Clin Sci Univ Bio Bio, Basic Sci Dept, Plant Biochem & Phytochem Ecol Lab Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med
關鍵字:	Raspberry seeds Fatty acids Extraction Antioxidant enzyme Hepatoprotection
日期:	2017-12
上傳時間:	2018-11-30 15:51:29 (UTC+8)
出版者:	Pergamon-Elsevier Science Ltd
摘要:	Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and gamma-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK)and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs. (C) 2017 Published by Elsevier Ltd.
關聯:	Food and Chemical Toxicology, v.110, pp.418-424
显示于类别:	[應用空間資訊系(所)] 期刊論文

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