Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents

doi:10.1016/j.fct.2017.09.010

CNU IR > College of Sustainable Environment and Recreation > Dept. of Applied Geoinformatics > Periodical Articles > Item 310902800/31648

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Title:	Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents
Authors:	Teng, Hui Lin, Qiyang Li, Kang Yuan, Benyao Song, Hongbo Peng, Hongquan Yi, Lunzhao Wei, Ming-Chi Yang, Yu-Chiao Battino, Maurizio Cespedes Acuna, Carlos L. Chen, Lei Xiao, Jianbo
Contributors:	Fujian Agr & Forestry Univ, Coll Food Sci Kiang Wu Hosp, Macau Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat Kaohsiung Med Univ, Dept & Grad Inst Pharmacol Univ Europea Atlantico, Ctr Nutr & Hlth Univ Europea, Univ Nutr & Hlth, Dept Clin Sci Univ Bio Bio, Basic Sci Dept, Plant Biochem & Phytochem Ecol Lab Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med
Keywords:	Raspberry seeds Fatty acids Extraction Antioxidant enzyme Hepatoprotection
Date:	2017-12
Issue Date:	2018-11-30 15:51:29 (UTC+8)
Publisher:	Pergamon-Elsevier Science Ltd
Abstract:	Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and gamma-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK)and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs. (C) 2017 Published by Elsevier Ltd.
Relation:	Food and Chemical Toxicology, v.110, pp.418-424
Appears in Collections:	[Dept. of Applied Geoinformatics] Periodical Articles

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