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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31648


    標題: Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents
    作者: Teng, Hui
    Lin, Qiyang
    Li, Kang
    Yuan, Benyao
    Song, Hongbo
    Peng, Hongquan
    Yi, Lunzhao
    Wei, Ming-Chi
    Yang, Yu-Chiao
    Battino, Maurizio
    Cespedes Acuna, Carlos L.
    Chen, Lei
    Xiao, Jianbo
    貢獻者: Fujian Agr & Forestry Univ, Coll Food Sci
    Kiang Wu Hosp, Macau
    Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst
    Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat
    Kaohsiung Med Univ, Dept & Grad Inst Pharmacol
    Univ Europea Atlantico, Ctr Nutr & Hlth
    Univ Europea, Univ Nutr & Hlth, Dept Clin Sci
    Univ Bio Bio, Basic Sci Dept, Plant Biochem & Phytochem Ecol Lab
    Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med
    關鍵字: Raspberry seeds
    Fatty acids
    Extraction
    Antioxidant enzyme
    Hepatoprotection
    日期: 2017-12
    上傳時間: 2018-11-30 15:51:29 (UTC+8)
    出版者: Pergamon-Elsevier Science Ltd
    摘要: Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and gamma-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK)and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs. (C) 2017 Published by Elsevier Ltd.
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