Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31408
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    CNU IR > Pharmacy and Science > 2016 >  Item 310902800/31408
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31408


    Title: Two polymethoxylated flavones exhibited an inhibitory effect on fibroblast-mediated breast tumorigenesis
    Authors: Wang, Chien-Chun
    Lin, Yo-An
    Yang, Bo-Kai
    Lee, Kuan-Han
    Vong, Wen-Jong
    Tyan, Shiaw-Wei
    Contributors: 嘉南藥理大學生物科技系
    嘉南藥理大學藥學系
    嘉南藥理大學新藥創建研究中心
    嘉南藥理大學醫藥化學系
    Date: 2016-05-10
    Issue Date: 2018-05-21 10:36:10 (UTC+8)
    Abstract: Some polymethoxylated flavones, such as sinensetin (5,6,7,3',4'-pentamethoxyflavone), isolated from citrus, have been shown to possess anti-cancer activity and lower toxicity. We synthesized two polymethoxylated flavones, which were sinensetin analogs, from 3,4,5-trimethoxyphenol in three steps. The inhibitory effects of the polymethoxylated flavones,3,4,5-trimethoxyphenol and a synthesis intermediate product on breast tumorigenesis and pancreatic tumorigenesis were tested. By using a co-culture system of cancer cells and fibroblasts, fibroblast-mediated colony formation of breast cancer MDA-MB-468 cells and pancreatic cancer PANC-1 cells in soft agar was examined with treatment of these compounds. The results showed that the polymethoxylated flavones and the intermediate product exhibited an inhibitory activity on colony formation of breast cancer MDA-MB-468 cells rather than colony formation of pancreatic cancer PANC-1 cells. In addition, the MTT assay revealed that the polymethoxylated flavones had low toxicity to MDA-MB-468 cells and fibroblasts. These results showed that the polymethoxylated flavones we synthesized possessed anti-breast tumorigenesis activity and low toxicity, which might offer potential chemotherapy in treatment of breast cancer.
    Appears in Collections:[Dept. of Medicinal Chemistry] Proceedings
    [Dept. of Pharmacy] Proceedings
    [Dept. of Biotechnology (including master's program)] Proceedings
    [Pharmacy and Science] 2016

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