Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31387
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18057/20255 (89%)
造访人次 : 1482052      在线人数 : 757
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31387


    標題: Evaluation the performance and application of vernal plant on skincare products
    作者: Chang, Tzu-Hsien
    貢獻者: Department Cosmetic Science and Institute of Cosmetic and Science, Chia Nan University of Pharmacy & Science, Taiwan
    Chia-Hua Liang
    日期: 2016-05-10
    上傳時間: 2018-05-21 10:35:49 (UTC+8)
    摘要: This study evaluated the anti-oxidation, DNA protection, anti-melanogenesis and anti-inflammatory properties of vernal plant on water (VPEW) and ethanol (VPEE) extraction. First, the preliminary tests confirmed that the VPEE better than VPEW, then we will further to evaluate VPEE on cell and animal experiments.
    In our study, we found that vernal plant extract shows less cytotoxicity in keratinocytes (HaCaT), melanoma (B16) and human fibroblasts (Hs68). In antioxidant experiments, VPEE had an excellent ability of free radical scavenging DPPH· and ABTS·+.Meanwhile, VPEE also decreased cellular oxidative stress, increased the intracellular GSH content and increased the amount of antioxidant enzyme expression. Otherwise, we also assessed that VPEE whether protected DNA form UVB and oxidants damage. VPEE inhibited the activity of HAase (hyaluronidase) and MMPs(Matrix metalloproteinases), DNA fragmentation, UVB Photoproducts (CPD, 6-4 PPs and PPs) formation and it promoted cellular collagen formation, would healing and regulated the protein expression of NER system(nuclear excision repair).
    Because of UVB and oxidant may cause the inflammatory response and skin pigmentation, so we assessed the properties of VPEE on anti-inflammatory and anti-melanogenesis as well. The data showed that VPEE inhibited the inflammatory factors (TNF-α, IL-1β and IL-6) release in HaCaT cells by LPS (lipidpolysaccharide) stimulation and it decreased the level of the inflammatory-related protein expression.
    Besides, VPEE inhibited the melanin secretion and intracellular tyrosinase activity. VPEE also decreased the melanogenesis related protein expression of melanoiflorin receptor (MC1R), microphthalmia-associated transcription factor(MITF), tyrosinase, tyrosinase-related protein-2(TRP-2) and tyrosinase-related protein-1(TRP-1).
    This study demonstrated that VPEE had the capacities of antioxidant, inhibiting of melanin formation; DNA protection and DNA repair as well as decreasing inflammatory factors production. VPEE had a potential to become a novel health care products or food additives on whitening, antioxidant and anti-inflammatory.
    關聯: 2016 第十屆嘉南藥理大學藥理學院師生研究成果發表會,起迄日:2016/05/10-2016/05/13,地點:嘉南藥理大學國際會議中心一樓
    显示于类别:[化妝品應用與管理系(所)] 會議論文
    [藥理學院] 2016 第十屆嘉南藥理大學藥理學院師生研究成果發表會

    文件中的档案:

    档案 描述 大小格式浏览次数
    D21.pdf490KbAdobe PDF306检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈