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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31033


    標題: Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods
    作者: Lee, Chia-Fen
    Zhang, Geng-Ming
    Nieh, Mu-Ping
    Don, Trong-Ming
    貢獻者: Chia Nan Univ Pharm & Sci, Inst Cosmet Sci, Dept Cosmet Sci
    Tamkang Univ, Dept Chem & Mat Engn
    Univ Connecticut, Inst Mat Sci, Polymer Program
    關鍵字: poly(N-isopropyl acrylamide)
    Gold nanorods
    Thermo-responsive
    Opto-thermal effect
    delivery
    日期: 2016-02
    上傳時間: 2018-01-18 11:40:16 (UTC+8)
    出版者: Elsevier Sci Ltd
    摘要: In this study, thermo-responsive poly(N-isopropyl acrylamide)-g-gold nanorods (PNIPAAm-g-GNRs) were prepared by grafting telechelic PNIPAAm-SH to the GNRs. They were stable in aqueous medium where the GNRs were protected by PNIPAAm chains as revealed by transmission electron microscope. The longitudinal surface plasmon absorbance had a red shift to 810 nm, and the lower critical solution temperature (LCST) of the PNIPAAm was increased to 34.9 degrees C. After being irradiated by near-IR for 5 min, the PNIPAAm-g-GNRs solution indicated a temperature increment above its LCST. The opto-thermal effect thus could induce the morphology change of the PNIPAAm, which was found to be reversible. Furthermore, the PNIPAAm-g-GNRs had a much lower cytotoxicity than the surfactant-stabilized GNRs. The cell viability of fibroblast after two days of culture could still reach 89.0% relative to the control. Therefore, the PNIPAAm-g-GNRs could be used as drug carriers in which the drug-release could be controlled by remote near-IR. (C) 2015 Elsevier Ltd. All rights reserved.
    關聯: Polymer, v.84, pp.138-147
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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