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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30967


    標題: Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy
    作者: Chao, Tung-Bo
    Li, Chien-Feng
    Lin, Ching-Yih
    Tian, Yu-Feng
    Chang, I-Wei
    Sheu, Ming-Jen
    Lee, Ying-En
    Chan, Ti-Chun
    He, Hong-Lin
    貢獻者: Yuans Gen Hosp, Dept Colorectal Surg
    Meiho Univ, Dept Hlth Business Adm
    Chi Mei Med Ctr, Dept Pathol
    Natl Hlth Res Inst, Natl Inst Canc Res
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Kaohsiung Med Univ, Inst Clin Med
    Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol
    Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management
    Chi Mei Med Ctr, Dept Surg, Div Gen Surg
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    I Shou Univ, E DA Hosp, Dept Pathol
    Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol
    關鍵字: chemoradiotherapy
    DSG3
    rectal cancer
    radiotherapy
    日期: 2016-06
    上傳時間: 2018-01-18 11:38:53 (UTC+8)
    出版者: Future Medicine Ltd
    摘要: Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
    關聯: Future Oncology, v.12 n.12, pp.1457-1467
    Appears in Collections:[保健營養系(所) ] 期刊論文

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