Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30967
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    Title: Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy
    Authors: Chao, Tung-Bo
    Li, Chien-Feng
    Lin, Ching-Yih
    Tian, Yu-Feng
    Chang, I-Wei
    Sheu, Ming-Jen
    Lee, Ying-En
    Chan, Ti-Chun
    He, Hong-Lin
    Contributors: Yuans Gen Hosp, Dept Colorectal Surg
    Meiho Univ, Dept Hlth Business Adm
    Chi Mei Med Ctr, Dept Pathol
    Natl Hlth Res Inst, Natl Inst Canc Res
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Kaohsiung Med Univ, Inst Clin Med
    Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol
    Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management
    Chi Mei Med Ctr, Dept Surg, Div Gen Surg
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    I Shou Univ, E DA Hosp, Dept Pathol
    Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol
    Keywords: chemoradiotherapy
    rectal cancer
    Date: 2016-06
    Issue Date: 2018-01-18 11:38:53 (UTC+8)
    Publisher: Future Medicine Ltd
    Abstract: Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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