Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

doi:10.2217/fon-2016-0071

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/30967

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/30967

Title:	Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy
Authors:	Chao, Tung-Bo Li, Chien-Feng Lin, Ching-Yih Tian, Yu-Feng Chang, I-Wei Sheu, Ming-Jen Lee, Ying-En Chan, Ti-Chun He, Hong-Lin
Contributors:	Yuans Gen Hosp, Dept Colorectal Surg Meiho Univ, Dept Hlth Business Adm Chi Mei Med Ctr, Dept Pathol Natl Hlth Res Inst, Natl Inst Canc Res Southern Taiwan Univ Sci & Technol, Dept Biotechnol Kaohsiung Med Univ, Inst Clin Med Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management Chi Mei Med Ctr, Dept Surg, Div Gen Surg Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr I Shou Univ, E DA Hosp, Dept Pathol Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol
Keywords:	chemoradiotherapy DSG3 rectal cancer radiotherapy
Date:	2016-06
Issue Date:	2018-01-18 11:38:53 (UTC+8)
Publisher:	Future Medicine Ltd
Abstract:	Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
Relation:	Future Oncology, v.12 n.12, pp.1457-1467
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	886	View/Open

Loading...