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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30962

    標題: Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells
    作者: Tu, Dom-Gene
    Lin, Wei-Ting
    Yu, Cheng-Chia
    Lee, Shiuan-Shinn
    Peng, Chih-Yu
    Lin, Taichen
    Yu, Chuan-Hang
    貢獻者: Ditmanson Med Fdn, Chia Yi Christian Hosp, Dept Nucl Med
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    Chang Jung Christian Univ, Coll Hlth Sci
    Ditmanson Med Fdn, Chia Yi Christian Hosp, Dept Oral & Maxillofacial Surg
    Chung Shan Med Univ, Sch Dent
    Chung Shan Med Univ Hosp, Dept Dent
    Chung Shan Med Univ, Inst Oral Sci
    Chung Shan Med Univ, Sch Publ Hlth
    關鍵字: cancer stem cells
    oral carcinomas
    日期: 2016-12
    上傳時間: 2018-01-18 11:38:48 (UTC+8)
    出版者: Elsevier Taiwan
    摘要: Background/Purpose: Previously, we successfully identified oral cancer stem cells (OCSC) displaying enhanced stemness and tumorigenic potentials. In the study, we investigated the chemotherapeutic effect of the flavonoid luteolin, commonly found in fruits and vegetables, on targeting OCSC. Methods: Oralspheres was applied to isolate OCSC. aldehyde dehydrogenase 1 activity and CD44 positivity of OCSC with luteolin treatment were assessed by flow cytometry analysis. Radio-sensitivity of OCSC treated with luteolin was examined. Invasion and colony-forming assays were performed to assess oncogenicity in OCSC. The expression of interleukin-6 (IL-6)/ signal transducer and activator of transcription 3 (STAT3) was examined by enzyme-linked immunosorbent assay and western blot analysis. Results: We showed that luteolin effectively inhibited the proliferation rate, self-renewal, aldehyde dehydrogenase 1 activity, and CD44 positivity of OCSC but did not cause significant cytotoxicity of normal epithelial cells. Moreover, luteolin restored radio-sensitivity in OCSC. Combined treatment with luteolin and radiation displayed synergistic effect on invasiveness and clonogenicity of OCSC. Mechanistically, treatment of luteolin resulted in inactivation of IL-6/STAT3 signaling. Conclusion: These results suggest that combined treatment of luteolin and radiation therapy can attenuate tumorigenicity of OCSC through IL-6/STAT3 signaling inactivation. Copyright (C) 2016, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
    關聯: Journal of the Formosan Medical Association, v.115 n.12, pp.1032-1038
    Appears in Collections:[ 食品科技系 ] 期刊論文

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