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| 標題: | Evaluation of Hirsutella sinensis Mycelium for Antifatigue Effect |
| 作者: | Wu, Lung-Yuan
Wu, Ming-Fang
Lu, Hsu-Feng
Liu, Chia-Hui
Lee, Ching-Hsiao
Chen, Yung-Liang
Hsueh, Shu-Ching
Yeh, Chun
Huang, Yi-Ping
Liu, Jia-You
Chung, Jing-Gung |
| 貢獻者: | 通識教育中心 |
| 關鍵字: | Hirsutella sinensis mycelium
antifatigue
forced swimming model |
| 日期: | 2015-03 |
| 上傳時間: | 2016-04-19 19:06:25 (UTC+8) |
| 出版者: | Int Inst Anticancer Research, Editorial Office 1St Km Kapandritiou-Kalamou Rd Kapandriti |
| 摘要: | The aim of this study was to investigate whether Hirsutella sinensis mycelium (HSM) has any antifatigue effect, using a forced swimming model in rats. Forty rats were randomly divided into five groups, each containing eight animals. The control group received 2 ml/kg body weight of distilled water and a positive control group was administered 1.13 ml/kg Quaker Essence of Chicken. The treated swimming groups were administered HSM powder manufactured by Chang Gung Biotechnology Corporation, Ltd., at doses of 63 mg/kg, 189 mg/kg or 378 mg/kg body weight/day, respectively for a period of six weeks. The above experiment was repeated with another 40 rats but for a period of eight weeks. At the end of the experiments, rats were placed in a swimming apparatus and the total swimming time until exhaustion was recorded. Pre-/post-exercise concentrations of serum urea nitrogen (BUN) and lactic acid were also determined. There were no deaths during the study. Physical and behavioral examinations did not reveal any treatment-related adverse effects after dosing. Changes in lactate levels were dose-dependent for the 8-but not the 6-week treatment. BUN levels were more affected by the 8-week treatment of HSM but not significantly altered in the 6-week treatment groups. The 8-week treatment groups showed a significant increase in swimming time to exhaustion compared to the control groups, which was not dose-dependent. For the 6-week treatment, only the middle and high doses increased swimming time to exhaustion. Conjugated diene contents were significantly higher in rats treated at any HSM dose for 8-weeks than the control groups. Swimming did not alter levels of liver glycogen when compared to the control sub-groups. Results of this study demonstrate that HSM improves physical endurance, which may be beneficial in treating conditions where fatigue is a factor and other antifatigue treatments are contraindicated |
| 關聯: | In Vivo, v.29 n.2, pp.263-267 |
| 顯示於類別: | [通識教育中心] 期刊論文
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