Evaluation of Hirsutella sinensis Mycelium for Antifatigue Effect

Chia Nan University of Pharmacy & Science Institutional Repository > 中心級單位 > 通識教育中心 > 期刊論文 > Item 310902800/29738

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/29738

標題:	Evaluation of Hirsutella sinensis Mycelium for Antifatigue Effect
作者:	Wu, Lung-Yuan Wu, Ming-Fang Lu, Hsu-Feng Liu, Chia-Hui Lee, Ching-Hsiao Chen, Yung-Liang Hsueh, Shu-Ching Yeh, Chun Huang, Yi-Ping Liu, Jia-You Chung, Jing-Gung
貢獻者:	通識教育中心
關鍵字:	Hirsutella sinensis mycelium antifatigue forced swimming model
日期:	2015-03
上傳時間:	2016-04-19 19:06:25 (UTC+8)
出版者:	Int Inst Anticancer Research, Editorial Office 1St Km Kapandritiou-Kalamou Rd Kapandriti
摘要:	The aim of this study was to investigate whether Hirsutella sinensis mycelium (HSM) has any antifatigue effect, using a forced swimming model in rats. Forty rats were randomly divided into five groups, each containing eight animals. The control group received 2 ml/kg body weight of distilled water and a positive control group was administered 1.13 ml/kg Quaker Essence of Chicken. The treated swimming groups were administered HSM powder manufactured by Chang Gung Biotechnology Corporation, Ltd., at doses of 63 mg/kg, 189 mg/kg or 378 mg/kg body weight/day, respectively for a period of six weeks. The above experiment was repeated with another 40 rats but for a period of eight weeks. At the end of the experiments, rats were placed in a swimming apparatus and the total swimming time until exhaustion was recorded. Pre-/post-exercise concentrations of serum urea nitrogen (BUN) and lactic acid were also determined. There were no deaths during the study. Physical and behavioral examinations did not reveal any treatment-related adverse effects after dosing. Changes in lactate levels were dose-dependent for the 8-but not the 6-week treatment. BUN levels were more affected by the 8-week treatment of HSM but not significantly altered in the 6-week treatment groups. The 8-week treatment groups showed a significant increase in swimming time to exhaustion compared to the control groups, which was not dose-dependent. For the 6-week treatment, only the middle and high doses increased swimming time to exhaustion. Conjugated diene contents were significantly higher in rats treated at any HSM dose for 8-weeks than the control groups. Swimming did not alter levels of liver glycogen when compared to the control sub-groups. Results of this study demonstrate that HSM improves physical endurance, which may be beneficial in treating conditions where fatigue is a factor and other antifatigue treatments are contraindicated
關聯:	In Vivo, v.29 n.2, pp.263-267
显示于类别:	[通識教育中心] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	1442	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....