English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17333/19639 (88%)
Visitors : 5235720      Online Users : 579
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29674

    標題: Djulis (Chenopodiun formosaneum) and its bioactive compounds protect against oxidative stress in human HepG2 cells
    作者: Chyau, Charng-Cherng
    Chu, Chin-Chen
    Chen, Shih-Ying
    Duh, Pin-Der
    貢獻者: 休閒保健管理系
    關鍵字: Apoptosis
    Djulis(Chenopodiun formosaneum)
    Oxidativ estress
    日期: 2015-10
    上傳時間: 2016-04-19 19:04:11 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: The effect of water extracts of Djulis (Chenopodiun formosaneum) (WECF) and its bioactive compounds on the oxidative stress of tert-butyl hydroperoxide (t-BHP)-induced HepG2 cells is investigated. WECF (at 10-250 mu g/ml) demonstrates a cytoprotection in 0.2 mM t-BHP-induced HepG2 cells. The oxidative damage was accompanied by depletion of glutathione (GSH), thiobarbituric acid reactive substances (TBARS) formation and reactive oxygen species (ROS) generation which was significantly reduced by WECF. There was a down-regulated degradation of I kappa B-alpha and anti-apoptosis in t-BHP-induced cells by WECF. The increase in the Bcl-2/Bax ratio and the mitochondrial membrane potential and a decrease in caspase-3 activity and the down-modulated degradation of poly ADP-ribose polymerase (PARP) by WECF in t-BHP-induced cells parallels the effect on cell viability. The anti-apoptosis in t-BHP-induced cells by WECF was verified by observation using DAPI staining assay. According to HPLC-DAD and HPLC-MS/MS analysis, betanin, rutin, kaempferol and another twenty compounds were present in WECF, which may partially be responsible for its protective effect against oxidative damage. Collectively, WECF consisting of bioactive compounds can prevent oxidative stress by enhancing the antioxidant indices and reducing apoptosis of cells.
    關聯: Journal of Functional Foods, v.18 Part A, pp.159-170
    Appears in Collections:[ 食品科技系 ] 期刊論文
    [保健營養系(所) ] 期刊論文
    [休閒保健管理系(所)] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback