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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29573


    標題: Lower Urinary Tract Symptoms Are Associated with Increased Risk of Dementia among the Elderly: A Nationwide Study
    作者: Chiang, Chi-Hsiang
    Wu, Ming-Ping
    Ho, Chung-Han
    Weng, Shih-Feng
    Huang, Chien-Cheng
    Hsieh, Wan-Ting
    Hsu, Ya-Wen
    Chen, Ping-Jen
    貢獻者: 通識教育中心
    醫務管理系
    關鍵字: Mild cognitive impairment
    Central-nervous-system
    Quality-of-life
    Alzheimers-disease
    Overactivebladder
    Older-adults
    Incontinence
    Burden
    Health
    Cohort
    日期: 2015
    上傳時間: 2016-04-19 19:00:43 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: Studies show a strong association between dementia and lower urinary tract symptoms (LUTS). The aim of this study was to investigate whether LUTS are a risk factor for cognitive impairment. We enrolled 50-year-old and older subjects with LUTS (LUTS[+]) (n = 6801) and controls without LUTS (LUTS[-]) (n = 20,403) from Taiwan's National Health Insurance Research Database. LUTS, dementia, and other confounding factors are defined by International Classification of Diseases, Ninth Revision, Clinical Modification Codes. Participants were recruited from 2000 to 2004 and then followed up until death or the end of 2011. The outcome was the onset of dementia, which was assessed using Poisson regression analysis, Cox hazards models, and Kaplan-Meier survival curves. The incidence of dementia was significantly higher in the LUTS[+] group than in the LUTS[-] group (124.76 versus 77.59/1000 person-years). The increased risk of dementia related to LUTS remained significant after adjustment for potential confounders (adjusted hazard ratio (AHR):1.61, 95% confidence interval (CI) 1.47-1.76, p < 0.0001) and higher than that related to cerebrovascular disease (AHR: 1.43, 95% CI 1.26-1.61, p < 0.0001). The outcome suggests the need for early screening and appropriate intervention to help prevent cognitive impairment of patients with LUTS.
    關聯: Biomed Research International, v.2015, Article ID 187819
    Appears in Collections:[醫務管理系(所)] 期刊論文
    [通識教育中心] 期刊論文

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