Lower Urinary Tract Symptoms Are Associated with Increased Risk of Dementia among the Elderly: A Nationwide Study

doi:10.1155/2015/187819

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Title:	Lower Urinary Tract Symptoms Are Associated with Increased Risk of Dementia among the Elderly: A Nationwide Study
Authors:	Chiang, Chi-Hsiang Wu, Ming-Ping Ho, Chung-Han Weng, Shih-Feng Huang, Chien-Cheng Hsieh, Wan-Ting Hsu, Ya-Wen Chen, Ping-Jen
Contributors:	通識教育中心醫務管理系
Keywords:	Mild cognitive impairment Central-nervous-system Quality-of-life Alzheimers-disease Overactivebladder Older-adults Incontinence Burden Health Cohort
Date:	2015
Issue Date:	2016-04-19 19:00:43 (UTC+8)
Publisher:	Hindawi Publishing Corporation
Abstract:	Studies show a strong association between dementia and lower urinary tract symptoms (LUTS). The aim of this study was to investigate whether LUTS are a risk factor for cognitive impairment. We enrolled 50-year-old and older subjects with LUTS (LUTS[+]) (n = 6801) and controls without LUTS (LUTS[-]) (n = 20,403) from Taiwan's National Health Insurance Research Database. LUTS, dementia, and other confounding factors are defined by International Classification of Diseases, Ninth Revision, Clinical Modification Codes. Participants were recruited from 2000 to 2004 and then followed up until death or the end of 2011. The outcome was the onset of dementia, which was assessed using Poisson regression analysis, Cox hazards models, and Kaplan-Meier survival curves. The incidence of dementia was significantly higher in the LUTS[+] group than in the LUTS[-] group (124.76 versus 77.59/1000 person-years). The increased risk of dementia related to LUTS remained significant after adjustment for potential confounders (adjusted hazard ratio (AHR):1.61, 95% confidence interval (CI) 1.47-1.76, p < 0.0001) and higher than that related to cerebrovascular disease (AHR: 1.43, 95% CI 1.26-1.61, p < 0.0001). The outcome suggests the need for early screening and appropriate intervention to help prevent cognitive impairment of patients with LUTS.
Relation:	Biomed Research International, v.2015, Article ID 187819
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles [The Center For General Education] Periodical Articles

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