Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29305
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    標題: Protective Effects of Selected Phenolic Compounds on Oxidative Stress
    作者: Tarnrat Pattanawong
    貢獻者: 保健營養系
    陳師瑩
    杜平惪
    關鍵字: Tarnrat Pattanawong
    antioxidant
    t-BHP
    oxidative stress
    HepG2 cells
    日期: 2014
    上傳時間: 2015-10-26 20:31:31 (UTC+8)
    摘要: The aim of this study was to evaluate the effect of selected phenolic compounds on oxidative stress. The phenolic compounds in the range of 50-500 ?g/ml showed no cytoxicity in the growth of HepG2 cells except Chrysin, Flavones, Galangin, and Baicalein.Flavonols, such as Quercetin, Morin, Myricetin, Rutin, Fisetin, and Kaemferol, and some phenolic acids such as Caffeic acid, and Chlorogenic, show greater protection on in the growth of HepG2 cells induced by 0.1 mM t-BHP than flavones, such as Chrysin, Baicalein, Apigenin, Nobilelin, and Tangeretin. For ROS generation, Quercetin, Morin, Myricetin, Rutin, Fisetin, Kaemferol, and Caffeic acid showed significant protection in these models. For mitochondrial membrane potential tests, Quercetin, Morin, Myricetin, Fisetin, Kaemferol, Caffeic acid and Chlorogenic acid showed significant protection mitochondrial membrane potential in these models. For the acellular tests, Quercetin, Morin, Myricetin, Rutin, Fisetin, Kaemferol, Caffeic acid, and Chlorogenic acid increased SOD activity and the inhibition of DPPH and NO. In cellular and acellular model systems, Quercetin, Morin, Myricetin, Rutin, Fisetin, Kaemferol, Caffeic, and Chlorogenic demonstrated significantly inhibitory effect on oxidative stress due to their remarkable antioxidant activity.
    顯示於類別:[保健營養系(所) ] 博碩士論文

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