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    Title: Protective Effects of Selected Phenolic Compounds on Oxidative Stress
    Authors: Tarnrat Pattanawong
    Contributors: 保健營養系
    Keywords: Tarnrat Pattanawong
    oxidative stress
    HepG2 cells
    Date: 2014
    Issue Date: 2015-10-26 20:31:31 (UTC+8)
    Abstract: The aim of this study was to evaluate the effect of selected phenolic compounds on oxidative stress. The phenolic compounds in the range of 50-500 ?g/ml showed no cytoxicity in the growth of HepG2 cells except Chrysin, Flavones, Galangin, and Baicalein.Flavonols, such as Quercetin, Morin, Myricetin, Rutin, Fisetin, and Kaemferol, and some phenolic acids such as Caffeic acid, and Chlorogenic, show greater protection on in the growth of HepG2 cells induced by 0.1 mM t-BHP than flavones, such as Chrysin, Baicalein, Apigenin, Nobilelin, and Tangeretin. For ROS generation, Quercetin, Morin, Myricetin, Rutin, Fisetin, Kaemferol, and Caffeic acid showed significant protection in these models. For mitochondrial membrane potential tests, Quercetin, Morin, Myricetin, Fisetin, Kaemferol, Caffeic acid and Chlorogenic acid showed significant protection mitochondrial membrane potential in these models. For the acellular tests, Quercetin, Morin, Myricetin, Rutin, Fisetin, Kaemferol, Caffeic acid, and Chlorogenic acid increased SOD activity and the inhibition of DPPH and NO. In cellular and acellular model systems, Quercetin, Morin, Myricetin, Rutin, Fisetin, Kaemferol, Caffeic, and Chlorogenic demonstrated significantly inhibitory effect on oxidative stress due to their remarkable antioxidant activity.
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Dissertations and Theses

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