Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28525
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    標題: Chronic Exposure to Rhodobacter Sphaeroides Extract Lycogen T Prevents UVA-Induced Malondialdehyde Accumulation and Procollagen I Down-Regulation in Human Dermal Fibroblasts
    作者: Yang, Tsai-Hsiu
    Lai, Ying-Hsiu
    Lin, Tsuey-Pin
    Liu, Wen-Sheng
    Kuan, Li-Chun
    Liu, Chia-Chyuan
    貢獻者: 保健營養系
    化粧品應用與管理系
    關鍵字: Lycogen
    skin aging
    UVA
    procollagen I
    matrix metalloproteinase
    日期: 2014-02
    上傳時間: 2015-05-06 21:19:25 (UTC+8)
    出版者: Mdpi Ag
    摘要: UVA contributes to the pathogenesis of skin aging by downregulation of procollagen I content and induction of matrix metalloproteinase (MMP)-associated responses. Application of antioxidants such as lycopene has been demonstrated as a convenient way to achieve protection against skin aging. Lycogen, derived from the extracts of Rhodobacter sphaeroides, exerts several biological effects similar to that of lycopene whereas most of its anti-aging efficacy remains uncertain. In this study, we attempted to examine whether Lycogen could suppress malondialdehyde (MDA) accumulation and restore downregulated procollagen I expression induced by UVA exposure. In human dermal fibroblasts Hs68 cells, UVA repressed cell viability and decreased procollagen I protein content accompanied with the induction of MMP-1 and MDA accumulation. Remarkably, incubation with 50 M Lycogen for 24 h ameliorated UVA-induced cell death and restored UVA-induced downregulation of procollagen in a dose-related manner. Lycogen treatment also prevented the UVA-induced MMP-1 upregulation and intracellular MDA generation in Hs68 cells. Activation of NFB levels, one of the downstream events induced by UVA irradiation and MMP-1 induction, were also prevented by Lycogen administration. Taken together, our findings demonstrate that Lycogen may be an alternative agent that prevents UVA-induced skin aging and could be used in cosmetic and pharmaceutical applications.
    關聯: International Journal of Molecular Sciences, v.15 n.2, pp.1686-1699
    显示于类别:[化妝品應用與管理系(所)] 期刊論文
    [保健營養系(所) ] 期刊論文

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