Chronic Exposure to Rhodobacter Sphaeroides Extract Lycogen T Prevents UVA-Induced Malondialdehyde Accumulation and Procollagen I Down-Regulation in Human Dermal Fibroblasts

doi:10.3390/ijms15021686

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/28525

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28525

Title:	Chronic Exposure to Rhodobacter Sphaeroides Extract Lycogen T Prevents UVA-Induced Malondialdehyde Accumulation and Procollagen I Down-Regulation in Human Dermal Fibroblasts
Authors:	Yang, Tsai-Hsiu Lai, Ying-Hsiu Lin, Tsuey-Pin Liu, Wen-Sheng Kuan, Li-Chun Liu, Chia-Chyuan
Contributors:	保健營養系化粧品應用與管理系
Keywords:	Lycogen skin aging UVA procollagen I matrix metalloproteinase
Date:	2014-02
Issue Date:	2015-05-06 21:19:25 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	UVA contributes to the pathogenesis of skin aging by downregulation of procollagen I content and induction of matrix metalloproteinase (MMP)-associated responses. Application of antioxidants such as lycopene has been demonstrated as a convenient way to achieve protection against skin aging. Lycogen, derived from the extracts of Rhodobacter sphaeroides, exerts several biological effects similar to that of lycopene whereas most of its anti-aging efficacy remains uncertain. In this study, we attempted to examine whether Lycogen could suppress malondialdehyde (MDA) accumulation and restore downregulated procollagen I expression induced by UVA exposure. In human dermal fibroblasts Hs68 cells, UVA repressed cell viability and decreased procollagen I protein content accompanied with the induction of MMP-1 and MDA accumulation. Remarkably, incubation with 50 M Lycogen for 24 h ameliorated UVA-induced cell death and restored UVA-induced downregulation of procollagen in a dose-related manner. Lycogen treatment also prevented the UVA-induced MMP-1 upregulation and intracellular MDA generation in Hs68 cells. Activation of NFB levels, one of the downstream events induced by UVA irradiation and MMP-1 induction, were also prevented by Lycogen administration. Taken together, our findings demonstrate that Lycogen may be an alternative agent that prevents UVA-induced skin aging and could be used in cosmetic and pharmaceutical applications.
Relation:	International Journal of Molecular Sciences, v.15 n.2, pp.1686-1699
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles [Dept. of Health and Nutrition (including master's program)] Periodical Articles

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