Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28525
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    Title: Chronic Exposure to Rhodobacter Sphaeroides Extract Lycogen T Prevents UVA-Induced Malondialdehyde Accumulation and Procollagen I Down-Regulation in Human Dermal Fibroblasts
    Authors: Yang, Tsai-Hsiu
    Lai, Ying-Hsiu
    Lin, Tsuey-Pin
    Liu, Wen-Sheng
    Kuan, Li-Chun
    Liu, Chia-Chyuan
    Contributors: 保健營養系
    化粧品應用與管理系
    Keywords: Lycogen
    skin aging
    UVA
    procollagen I
    matrix metalloproteinase
    Date: 2014-02
    Issue Date: 2015-05-06 21:19:25 (UTC+8)
    Publisher: Mdpi Ag
    Abstract: UVA contributes to the pathogenesis of skin aging by downregulation of procollagen I content and induction of matrix metalloproteinase (MMP)-associated responses. Application of antioxidants such as lycopene has been demonstrated as a convenient way to achieve protection against skin aging. Lycogen, derived from the extracts of Rhodobacter sphaeroides, exerts several biological effects similar to that of lycopene whereas most of its anti-aging efficacy remains uncertain. In this study, we attempted to examine whether Lycogen could suppress malondialdehyde (MDA) accumulation and restore downregulated procollagen I expression induced by UVA exposure. In human dermal fibroblasts Hs68 cells, UVA repressed cell viability and decreased procollagen I protein content accompanied with the induction of MMP-1 and MDA accumulation. Remarkably, incubation with 50 M Lycogen for 24 h ameliorated UVA-induced cell death and restored UVA-induced downregulation of procollagen in a dose-related manner. Lycogen treatment also prevented the UVA-induced MMP-1 upregulation and intracellular MDA generation in Hs68 cells. Activation of NFB levels, one of the downstream events induced by UVA irradiation and MMP-1 induction, were also prevented by Lycogen administration. Taken together, our findings demonstrate that Lycogen may be an alternative agent that prevents UVA-induced skin aging and could be used in cosmetic and pharmaceutical applications.
    Relation: International Journal of Molecular Sciences, v.15 n.2, pp.1686-1699
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
    [Dept. of Health and Nutrition (including master's program)] Periodical Articles

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