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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27943


    標題: The Inhibitory Effects of Aqueous Extract from Guava Twigs, Psidium guajava L., on Mutation and Oxidative Damage
    作者: Kang, Zhi-Chyang
    Yen, Ming-Tsung
    Chiu, Chih-Kwang
    Wu, Horng-Cherng
    Huang, Shu-Ling
    Tai, Shan-Pao
    Wang, Bor-Sen
    貢獻者: 生活應用與保健系
    保健營養系
    食品科技系
    關鍵字: Mutagenicity
    Diseases
    Rats
    日期: 2013
    上傳時間: 2014-05-26 10:50:00 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: This study examines the inhibitory effects of the aqueous extract from guava twigs (GTE), Psidium guajava L., on mutation and oxidative damage. The results show that GTE inhibits the mutagenicity of 4-nitroquinoline-N-oxide (4-NQO), a direct mutagen, and 2-aminoanthracene (2-AA), an indirect mutagen, toward Salmonella typhimurium TA 98 and TA 100. In addition, GTE shows radical scavenging, reducing activities, tyrosinase inhibition, and liposome protection effects. Meanwhile, GTE in the range of 0.1-0.4 mg/mL protects liver cells from tert-butyl-hydroperoxide-(t-BHP-) induced cytotoxicity. Furthermore, the cytotoxicity inhibition of GTE in the t-BHP-treated cells was demonstrated in a dose-dependent manner. High-performance liquid chromatography analysis suggests that the major phenolic constituents in GTE are gallic acid, ferulic acid, and myricetin. These active phenolic components may contribute to the biological protective effects of GTE in different models. The data suggest that GTE exhibiting biological activities can be applied to antimutation, antityrosinase, and antioxidative damage.
    關聯: Journal of Chemistry, v.2013 n.561905
    Appears in Collections:[生活應用與保健系] 期刊論文
    [保健營養系(所) ] 期刊論文
    [ 食品科技系 ] 期刊論文

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