The Inhibitory Effects of Aqueous Extract from Guava Twigs, Psidium guajava L., on Mutation and Oxidative Damage

doi:10.1155/2013/561905

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Title:	The Inhibitory Effects of Aqueous Extract from Guava Twigs, Psidium guajava L., on Mutation and Oxidative Damage
Authors:	Kang, Zhi-Chyang Yen, Ming-Tsung Chiu, Chih-Kwang Wu, Horng-Cherng Huang, Shu-Ling Tai, Shan-Pao Wang, Bor-Sen
Contributors:	生活應用與保健系保健營養系食品科技系
Keywords:	Mutagenicity Diseases Rats
Date:	2013
Issue Date:	2014-05-26 10:50:00 (UTC+8)
Publisher:	Hindawi Publishing Corporation
Abstract:	This study examines the inhibitory effects of the aqueous extract from guava twigs (GTE), Psidium guajava L., on mutation and oxidative damage. The results show that GTE inhibits the mutagenicity of 4-nitroquinoline-N-oxide (4-NQO), a direct mutagen, and 2-aminoanthracene (2-AA), an indirect mutagen, toward Salmonella typhimurium TA 98 and TA 100. In addition, GTE shows radical scavenging, reducing activities, tyrosinase inhibition, and liposome protection effects. Meanwhile, GTE in the range of 0.1-0.4 mg/mL protects liver cells from tert-butyl-hydroperoxide-(t-BHP-) induced cytotoxicity. Furthermore, the cytotoxicity inhibition of GTE in the t-BHP-treated cells was demonstrated in a dose-dependent manner. High-performance liquid chromatography analysis suggests that the major phenolic constituents in GTE are gallic acid, ferulic acid, and myricetin. These active phenolic components may contribute to the biological protective effects of GTE in different models. The data suggest that GTE exhibiting biological activities can be applied to antimutation, antityrosinase, and antioxidative damage.
Relation:	Journal of Chemistry, v.2013 n.561905
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles [Dept. of Health and Nutrition (including master's program)] Periodical Articles [Dept. of Food Science & Technology] Periodical Articles

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