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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27872


    標題: Inhibitory effects of water extract of Flos Inulae on mutation and tyrosinase
    作者: Huang, Ming-Hsing
    Tai, Huo-Mu
    Wang, Bor-Sen
    Chang, Lee-Wen
    貢獻者: 生活應用與保健系
    化妝品應用與管理系
    食品科技系
    關鍵字: Flos Inulae
    Mutation
    Tyrosinase
    Oxidative Damage
    日期: 2013-07
    上傳時間: 2014-05-26 10:47:06 (UTC+8)
    出版者: Elsevier Sci Ltd
    摘要: In this study, the effects of a water extract of Flos Inulae (WFI) on antioxidant, antimutation and antityrosinase were investigated. The results showed that WFI inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mutagen; and 4-nitroquinoline-N-oxide (4-NQO), a direct mutagen toward Salmonella typhimurium TA 98 and TA 100. In addition, WFI, in the range of 0.2-0.6 mg/ml, showed radical scavenging, reducing activities and chelating activity as well as decreased lipid oxidative damage. Meanwhile, WFI also inhibited tyrosinase activity and NO generation in lipopolysaccharide (LPS) stimulated macrophages. High performance liquid chromatography analysis suggests that the major phenolic constituents in WFI are chlorogenic acid, rutin, quercetin, luteolin and kaempferol. These bioactive components may contribute to the protective effects of WFI. The obtained data suggests that Flos Inulae can be applied to antimutation, antityrosinase and anti-inflammation. (C) 2013 Elsevier Ltd. All rights reserved.
    Appears in Collections:[生活應用與保健系] 期刊論文
    [化妝品應用與管理系(所)] 期刊論文
    [ 食品科技系 ] 期刊論文

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