Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27872
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    Title: Inhibitory effects of water extract of Flos Inulae on mutation and tyrosinase
    Authors: Huang, Ming-Hsing
    Tai, Huo-Mu
    Wang, Bor-Sen
    Chang, Lee-Wen
    Contributors: 生活應用與保健系
    化妝品應用與管理系
    食品科技系
    Keywords: Flos Inulae
    Mutation
    Tyrosinase
    Oxidative Damage
    Date: 2013-07
    Issue Date: 2014-05-26 10:47:06 (UTC+8)
    Publisher: Elsevier Sci Ltd
    Abstract: In this study, the effects of a water extract of Flos Inulae (WFI) on antioxidant, antimutation and antityrosinase were investigated. The results showed that WFI inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mutagen; and 4-nitroquinoline-N-oxide (4-NQO), a direct mutagen toward Salmonella typhimurium TA 98 and TA 100. In addition, WFI, in the range of 0.2-0.6 mg/ml, showed radical scavenging, reducing activities and chelating activity as well as decreased lipid oxidative damage. Meanwhile, WFI also inhibited tyrosinase activity and NO generation in lipopolysaccharide (LPS) stimulated macrophages. High performance liquid chromatography analysis suggests that the major phenolic constituents in WFI are chlorogenic acid, rutin, quercetin, luteolin and kaempferol. These bioactive components may contribute to the protective effects of WFI. The obtained data suggests that Flos Inulae can be applied to antimutation, antityrosinase and anti-inflammation. (C) 2013 Elsevier Ltd. All rights reserved.
    Relation: Food Chemistry, v.139 n.41278, pp.1015-1020
    Appears in Collections:[Dept. of Life and Health Science] Periodical Articles
    [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
    [Dept. of Food Science & Technology] Periodical Articles

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