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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27529


    標題: Room-temperature super-extraction system (RTSES) optimizes the anxiolytic- and antidepressant-like behavioural effects of traditional Xiao-Yao-San in mice
    作者: Yin, Shih-Hsi
    Wang, Ching-Cheng
    Cheng, Tain-Junn
    Chang, Chia-Yu
    Lin, Kao-Chang
    Kan, Wei-Chih
    Wang, Hsien-Yi
    Kao, Wenny Mei-Wen
    Kuo, Yen-Liang
    Chen, Jian-Chyi
    Li, Shun-Lai
    Cheng, Chia-Hui
    Chuu, Jiunn-Jye
    貢獻者: 職業安全衛生系
    關鍵字: Chinese Herbal Medicines
    Kami-Shoyo-San
    Intact Rat
    Fluoxetine
    Release
    Insulin
    Anxiety
    Disability
    Depression
    Locomotion
    日期: 2012-11-07
    上傳時間: 2014-03-21 16:12:31 (UTC+8)
    出版者: Biomed Central Ltd
    摘要: Background: Xiao-Yao-San (XYS) is a Chinese medicinal formula for treating anxiety and depression. This study aims to evaluate the use of a room-temperature super-extraction system (RTSES) to extract the major active components of XYS and enhance their psycho-pharmacological effects.Methods: The neuroprotective roles of XYS/RTSES against reserpine-derived neurotoxicity were evaluated using a glial cell injury system (in vitro) and a depression-like C57BL/6 J mouse model (in vivo). The anxiolytic-behavioural effects were measured by the elevated plus-maze (EPM) test and the antidepressant effects were evaluated by the forced swimming test (FST) and tail suspension test (TST). Glucose tolerance and insulin resistance were assayed by ELISA. The expression of 5-HT1A receptors in the prefrontal cortex was examined by western blotting.Results: XYS/RTSES (300 mu g/mL) diminished reserpine-induced glial cell death more effectively than either XYS (300 mu g/mL) or fluoxetine (30 mu M) at 24 h (P = 0.0481 and P = 0.054, respectively). Oral administration of XYS/RTSES (500 mg/kg/day) for 4 consecutive weeks significantly elevated the ratios of entries (open arms/closed arms; P = 0.0177) and shuttle activity (P = 0.00149) on the EPM test, and reduced the immobility time by 90% on the TST (P = 0.00000538) and FST (P = 0.0000053839). XYS/RTSES also improved the regulation of blood glucose (P = 0.0305) and increased the insulin sensitivity (P = 0.0093). The Western blot results indicated that the activation of cerebral 5-HT1A receptors may be involved in the mechanisms of XYS/RTSES actions.Conclusion: The RTSES could provide a novel method for extracting effective anxiolytic- and antidepressant-like substances. XYS/RTSES improved the regulation of blood glucose and increased the insulin sensitivity in reserpine-induced anxiety and depression. Neuroprotection of glial cells and activation of cerebral 5-HT1A receptors were also involved.
    Appears in Collections:[職業安全衛生系(含防災所)] 期刊論文

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