Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27529
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17109/19415 (88%)
造访人次 : 2691960      在线人数 : 750
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/27529


    標題: Room-temperature super-extraction system (RTSES) optimizes the anxiolytic- and antidepressant-like behavioural effects of traditional Xiao-Yao-San in mice
    作者: Yin, Shih-Hsi
    Wang, Ching-Cheng
    Cheng, Tain-Junn
    Chang, Chia-Yu
    Lin, Kao-Chang
    Kan, Wei-Chih
    Wang, Hsien-Yi
    Kao, Wenny Mei-Wen
    Kuo, Yen-Liang
    Chen, Jian-Chyi
    Li, Shun-Lai
    Cheng, Chia-Hui
    Chuu, Jiunn-Jye
    貢獻者: 職業安全衛生系
    關鍵字: Chinese Herbal Medicines
    Kami-Shoyo-San
    Intact Rat
    Fluoxetine
    Release
    Insulin
    Anxiety
    Disability
    Depression
    Locomotion
    日期: 2012-11-07
    上傳時間: 2014-03-21 16:12:31 (UTC+8)
    出版者: Biomed Central Ltd
    摘要: Background: Xiao-Yao-San (XYS) is a Chinese medicinal formula for treating anxiety and depression. This study aims to evaluate the use of a room-temperature super-extraction system (RTSES) to extract the major active components of XYS and enhance their psycho-pharmacological effects.Methods: The neuroprotective roles of XYS/RTSES against reserpine-derived neurotoxicity were evaluated using a glial cell injury system (in vitro) and a depression-like C57BL/6 J mouse model (in vivo). The anxiolytic-behavioural effects were measured by the elevated plus-maze (EPM) test and the antidepressant effects were evaluated by the forced swimming test (FST) and tail suspension test (TST). Glucose tolerance and insulin resistance were assayed by ELISA. The expression of 5-HT1A receptors in the prefrontal cortex was examined by western blotting.Results: XYS/RTSES (300 mu g/mL) diminished reserpine-induced glial cell death more effectively than either XYS (300 mu g/mL) or fluoxetine (30 mu M) at 24 h (P = 0.0481 and P = 0.054, respectively). Oral administration of XYS/RTSES (500 mg/kg/day) for 4 consecutive weeks significantly elevated the ratios of entries (open arms/closed arms; P = 0.0177) and shuttle activity (P = 0.00149) on the EPM test, and reduced the immobility time by 90% on the TST (P = 0.00000538) and FST (P = 0.0000053839). XYS/RTSES also improved the regulation of blood glucose (P = 0.0305) and increased the insulin sensitivity (P = 0.0093). The Western blot results indicated that the activation of cerebral 5-HT1A receptors may be involved in the mechanisms of XYS/RTSES actions.Conclusion: The RTSES could provide a novel method for extracting effective anxiolytic- and antidepressant-like substances. XYS/RTSES improved the regulation of blood glucose and increased the insulin sensitivity in reserpine-induced anxiety and depression. Neuroprotection of glial cells and activation of cerebral 5-HT1A receptors were also involved.
    显示于类别:[職業安全衛生系(含防災所)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML424检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈