Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25391
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    標題: Unraveling polyketide synthesis in members of the genus Aspergillus
    作者: Yi-Ming Chiang
    Berl R. Oakley
    Nancy P. Keller
    Clay C. C. Wang
    貢獻者: 藥物科技研究所
    關鍵字: Secondary metabolites
    Fungi
    Polyketide
    Nonribosomal peptides
    日期: 2010-05
    上傳時間: 2012-06-04 16:40:19 (UTC+8)
    摘要: Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.
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