Unraveling polyketide synthesis in members of the genus Aspergillus

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/25391

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/25391

Title:	Unraveling polyketide synthesis in members of the genus Aspergillus
Authors:	Yi-Ming Chiang Berl R. Oakley Nancy P. Keller Clay C. C. Wang
Contributors:	藥物科技研究所
Keywords:	Secondary metabolites Fungi Polyketide Nonribosomal peptides
Date:	2010-05
Issue Date:	2012-06-04 16:40:19 (UTC+8)
Abstract:	Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.
Relation:	Applied Microbiology and Biotechnology 86(6)：p.1719-1736
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

Files in This Item:

File	Description	Size	Format
99_163_j.pdf		2342Kb	Adobe PDF	250	View/Open
index.html		0Kb	HTML	1922	View/Open