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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/25133

    標題: Antioxidative characteristics and inhibition of α-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare
    作者: Tzung-Han Chou
    Hsiou-Yu Ding
    Wei Jing Hung
    Chia-Hua Liang
    貢獻者: 化粧品科技研究所
    關鍵字: antioxidant
    Origanum vulgare
    vanillic acid
    日期: 2010-08
    上傳時間: 2012-03-29 13:45:50 (UTC+8)
    摘要: The antioxidant activities of vanillin and vanillic acid isolated from Origanum vulgare are investigated. These compounds may serve as agents for antimelanogenesis. Vanillic acid is a stronger antioxidant than vanillin, in terms of free radical scavenging activity, reducing power and inhibition of lipid peroxidation. The inhibition of cellular reactive oxygen species (ROS) in H2O2-treated BNLCL2 cells by vanillic acid exceeds that of ascorbic acid (AA) or trolox. In B16F0 cells stimulated with α-melanocyte-stimulating hormone (α-MSH), vanillic acid reduced cellular tyrosinase activity, DOPA oxidase and melanin contents, as well as down-regulated expressions of melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related proteins 2 (TRP-2) and TRP-1. Vanillin did not express inhibition of tyrosinase activity. These results supported that vanillic acid is a significantly stronger antioxidant than vanillin and exhibited stronger antimelanogenesis performance because of the structural presence of the carboxyl group
    關聯: Experimental Dermatology 19(8):p.742-750
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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