Antioxidative characteristics and inhibition of α-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare

doi:10.1111/j.1600-0625.2010.01091.x

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/25133

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/25133

Title:	Antioxidative characteristics and inhibition of α-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare
Authors:	Tzung-Han Chou Hsiou-Yu Ding Wei Jing Hung Chia-Hua Liang
Contributors:	化粧品科技研究所
Keywords:	antioxidant antimelanogenic Origanum vulgare vanillin vanillic acid
Date:	2010-08
Issue Date:	2012-03-29 13:45:50 (UTC+8)
Abstract:	The antioxidant activities of vanillin and vanillic acid isolated from Origanum vulgare are investigated. These compounds may serve as agents for antimelanogenesis. Vanillic acid is a stronger antioxidant than vanillin, in terms of free radical scavenging activity, reducing power and inhibition of lipid peroxidation. The inhibition of cellular reactive oxygen species (ROS) in H2O2-treated BNLCL2 cells by vanillic acid exceeds that of ascorbic acid (AA) or trolox. In B16F0 cells stimulated with α-melanocyte-stimulating hormone (α-MSH), vanillic acid reduced cellular tyrosinase activity, DOPA oxidase and melanin contents, as well as down-regulated expressions of melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related proteins 2 (TRP-2) and TRP-1. Vanillin did not express inhibition of tyrosinase activity. These results supported that vanillic acid is a significantly stronger antioxidant than vanillin and exhibited stronger antimelanogenesis performance because of the structural presence of the carboxyl group
Relation:	Experimental Dermatology 19(8)：p.742-750
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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