標的導向型磁性免疫藥物載體之合成及其實際應用之研究(II)

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > MOST Project > Item 310902800/2399

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/2399

Title:	標的導向型磁性免疫藥物載體之合成及其實際應用之研究(II)
Authors:	李佳芬
Contributors:	化妝品應用與管理系
Date:	2005
Issue Date:	2008-07-31 14:37:50 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學化妝品應用與管理系
Abstract:	本論文以氮- 異丙基丙烯醯胺 (N-isopropylacrylamide，NIPAAM)和丙烯酸(acrylic acid， AA)的乳膠顆粒，在改變AA/NIPAAM 比例及交聯劑濃度下進行各項測試。接著進行磁性乳膠顆粒的製備實驗，與傳統“氧化鐵/ 高分子”合成方法有所不同，本實驗先將高分子乳膠顆粒合成，利用乳膠顆粒的AA 鏈段官能基(-COOH)與鐵離子先鍵結成-COOFe2+及-COOFe3+，當氨水參與反應時， Fe3O4 會以in-situ 的方式形成，於是磁性乳膠顆粒形成。 TEM 圖形下觀察粒徑大小及型態；利用紫外光-可見光分光光度計在改變溫度下測量450nm 下的吸收值變化，得出LCST 變化；利用紫外光-可見光分光光度計在 272nm，於不同時間下取樣測試咖啡因濃度－藥物包覆釋放實驗；利用紫外光-可見光分光光度計在280nm 測試不同組別的BSA 濃度，可反推鍵結上的BSA 含量。 In our study, we discuss the copolymer of NIPAAM (N-isopropylacrylamide) and AA (acrylic acid) in different ratio of AA/NIPAAM and in different concentration of crosslinking agent. We test this copolymer in some experiments incluiding TEM, LCST, drug release and protein (BSA) bonding. Then synthesizing the magnetic hydrogel, we use different method to synthesize “iron oxide/polymer” form the traditional method. In our work, we firstly synthesize the hydrogel. Second, using the functional group(-COOH) on the hyrogel surface to bond with Fe2+ and Fe3+. Finally, we put ammonia into the latex, and we can get magnetic hydrogel. According to each test about poly(NIPAAM-co-AA), we choose suitable group to synthesize magnetic hydrogel. Then we test all events described in the first paragraph. From all testing experiments, we can realize the properties of the (magnetic) hydrogel and the effect on experimental results from each parameter.
Relation:	計畫編號： NSC94-2216-E-041-002
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] MOST Project

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