English  |  正體中文  |  简体中文  |  Items with full text/Total items : 16812/19099 (88%)
Visitors : 6863430      Online Users : 750
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/23261


    標題: Change of serum vascular adhesion protein-1 after glucose loading correlates to carotid intima-medial thickness in non-diabetic subjects
    作者: Hung-Yuan Li
    Mao-Shin Lin
    Jung-Nan Wei
    Chi Sheng Hung
    Fu-Tien Chiang
    Cheng-Hsin Lin
    Hsiu-Ching Hsu
    Chien-Yin Su
    Mei-Yu Wu
    David J. Smith
    Jani Vainio
    Ming-Fong Chen
    Lee-Ming Chuang
    貢獻者: 職業安全衛生系
    關鍵字: Carotid intima-medial thickness
    Vascular adhesion protein-1
    Oxidative stress
    Advanced glycated end products
    日期: 2009-05
    上傳時間: 2010-11-19 11:50:11 (UTC+8)
    摘要: Background
    We investigated if serum vascular adhesion protein-1 (SSAO/VAP-1) changed acutely following oral glucose loading and whether such changes are correlated with surrogate markers of atherosclerosis.

    Methods
    A total of 115 non-diabetics subjects were enrolled for an oral glucose tolerance test (OGTT). Carotid intima-medial thickness (IMT) was measured by ultrasonography. Serum SSAO/VAP-1 was analyzed by time-resolved immunofluorometric assay. Serum thiobarbituric acid reactive substances (TBARS) and advanced glycated end products (AGEs) were measured by fluorometric assays.

    Results
    Serum SSAO/VAP-1 increased significantly at 30 min after oral glucose loading and lasted to 2 h (p = 0.0005 and p < 0.0001, for 30 min and 2 h respectively). The area under curve of serum SSAO/VAP-1 during OGTT (AUC-VAP-1) correlated significantly with carotid IMT, independent of age, gender, low-density lipoprotein cholesterol, systolic blood pressure, hemoglobin A1c, serum TBARS, AGEs, and high-sensitivity C-reactive protein. Subjects with a positive AUC-VAP-1 had significantly higher serum TBARS and AGEs than subjects with a negative AUC-VAP-1 adjusted for age and gender.

    Conclusions
    Serum SSAO/VAP-1 changed acutely following oral glucose loading in non-diabetic subjects. Change of serum SSAO/VAP-1 correlated independently to serum TBARS, AGEs, and carotid IMT. Our findings suggest that acute change of serum SSAO/VAP-1 is a novel marker for hyperglycemia-induced atherosclerosis.
    關聯: Clinica Chimica Acta 403(1-2):p.97-101
    Appears in Collections:[職業安全衛生系(含防災所)] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML1079View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback