Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/23261
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    Title: Change of serum vascular adhesion protein-1 after glucose loading correlates to carotid intima-medial thickness in non-diabetic subjects
    Authors: Hung-Yuan Li
    Mao-Shin Lin
    Jung-Nan Wei
    Chi Sheng Hung
    Fu-Tien Chiang
    Cheng-Hsin Lin
    Hsiu-Ching Hsu
    Chien-Yin Su
    Mei-Yu Wu
    David J. Smith
    Jani Vainio
    Ming-Fong Chen
    Lee-Ming Chuang
    Contributors: 職業安全衛生系
    Keywords: Carotid intima-medial thickness
    Vascular adhesion protein-1
    Oxidative stress
    Advanced glycated end products
    Date: 2009-05
    Issue Date: 2010-11-19 11:50:11 (UTC+8)
    Abstract: Background
    We investigated if serum vascular adhesion protein-1 (SSAO/VAP-1) changed acutely following oral glucose loading and whether such changes are correlated with surrogate markers of atherosclerosis.

    Methods
    A total of 115 non-diabetics subjects were enrolled for an oral glucose tolerance test (OGTT). Carotid intima-medial thickness (IMT) was measured by ultrasonography. Serum SSAO/VAP-1 was analyzed by time-resolved immunofluorometric assay. Serum thiobarbituric acid reactive substances (TBARS) and advanced glycated end products (AGEs) were measured by fluorometric assays.

    Results
    Serum SSAO/VAP-1 increased significantly at 30 min after oral glucose loading and lasted to 2 h (p = 0.0005 and p < 0.0001, for 30 min and 2 h respectively). The area under curve of serum SSAO/VAP-1 during OGTT (AUC-VAP-1) correlated significantly with carotid IMT, independent of age, gender, low-density lipoprotein cholesterol, systolic blood pressure, hemoglobin A1c, serum TBARS, AGEs, and high-sensitivity C-reactive protein. Subjects with a positive AUC-VAP-1 had significantly higher serum TBARS and AGEs than subjects with a negative AUC-VAP-1 adjusted for age and gender.

    Conclusions
    Serum SSAO/VAP-1 changed acutely following oral glucose loading in non-diabetic subjects. Change of serum SSAO/VAP-1 correlated independently to serum TBARS, AGEs, and carotid IMT. Our findings suggest that acute change of serum SSAO/VAP-1 is a novel marker for hyperglycemia-induced atherosclerosis.
    Relation: Clinica Chimica Acta 403(1-2):p.97-101
    Appears in Collections:[Dept. of Occupational Safety] Periodical Articles

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