Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/23000
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    CNU IR > Chna Nan Annual Bulletin > Vol.23 (1997) >  Item 310902800/23000
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    Title: Distribution of Free and Liposome-encapsulated Norfloxacin in Rat Skin following Topical Administratin
    Authors: 林恆弘
    Contributors: 藥學系
    Keywords: Norfloxacin
    Transdermal delivery
    rat skin
    Date: 1997
    Issue Date: 2010-08-11 11:28:49 (UTC+8)
    Abstract: The effect of liposome encapsulation on the percutaneous absorption of norfloxacin through rat skin were examined in vitro and in vivo. In the in vitro transdermal perfusion studies of norfloxacin loaded-liposomes, lipsomal norfloxacin would increase the loading of the drug in stratum corneum. Moreover, the drainage of liposomes from the stratum corneum was somewhat slower than the drug solution from. The increase in the drug retention or stratum corneum for the lipids conformed to the following order: DSPC>DPPC>DMPC. In the in vivo studies, a good correlation was observed between the AUC0-8 in vivo and the flux for permeation experimens in vitro.However, topical applications of liposomal preparations of norfloxacin result in higher and long-lasting amount of drug in the rat skin as compare to oral administration or norfloxacin solution.The liposomal formulations show great potential as a topical drug delivery system.
    Relation: 嘉南學報 23期: p.34-41
    Appears in Collections:[Chna Nan Annual Bulletin] Vol.23 (1997)
    [Dept. of Pharmacy] Periodical Articles

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