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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22288


    標題: The effect of centaurein on interferon-γ expression and Listeria infection in mice
    作者: Shu-Lin Chang
    Hsu-Hua Yeh
    Yu-Shiun Lin
    Yi-Ming Chiang
    Tung-Kung Wu
    Wen-Chin Yang
    貢獻者: 藥物科技研究所
    關鍵字: Centaurein
    IFN-γ
    Listeria
    Flavonoid
    日期: 2007-02
    上傳時間: 2010-01-15 14:39:48 (UTC+8)
    摘要: We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.
    關聯: Toxicology and Applied Pharmacology 219(1): p.54-61
    Appears in Collections:[藥學系(所)] 期刊論文

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