The effect of centaurein on interferon-γ expression and Listeria infection in mice

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Title:	The effect of centaurein on interferon-γ expression and Listeria infection in mice
Authors:	Shu-Lin Chang Hsu-Hua Yeh Yu-Shiun Lin Yi-Ming Chiang Tung-Kung Wu Wen-Chin Yang
Contributors:	藥物科技研究所
Keywords:	Centaurein IFN-γ Listeria Flavonoid
Date:	2007-02
Issue Date:	2010-01-15 14:39:48 (UTC+8)
Abstract:	We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.
Relation:	Toxicology and Applied Pharmacology 219(1)： p.54-61
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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