本研究利用聚電解質複合法 (polyelectrolyte complexes，PECs) 將幾丁聚醣(Chitosan)高分子膠體/阿斯匹靈(Aspirin)溶於醋酸溶液中，做物理性的摻合形成含藥之高分子膠體溶液。再將高分子膠體與三聚磷酸鈉(TPP)和羧甲基纖維素(CMC)進行聚電解質複合反應(polyelectrolyte complexation)，得到複合式藥物顆粒。改變CMC濃度和Aspirin添加量之反應條件以得到不同的Chit/Asp/CMC膠體顆粒(Gel Beads)，探討製備條件藥物包埋量、藥物顆粒粒徑、藥物顆粒重量平均粒徑、顆粒表面型態、釋放環境 (pH 2、4、7)、顆粒物理結構對藥物釋放模式之影響。結果發現藥物顆粒之藥物釋放模式為T.Higuchi動力模式，並具藥物控制釋放的效能。 The purpose of this study was the preparation and characterization of drug containing polymer gel beads. Natural and biocompatible chitosan was dissolved with drug in 5 wt% acetic acid solution. Different chitosan gel beads were obtained by polyelectrolyte complexation with sodium salt of carboxymethyl cellulose and tripolyphosphate. The effect of drug entrap ratio, gel particle size, morphology and physical properties on drug released behavior were investigated. The results showed that the drug can sustain 16 hrs and its release rate was consistent with T. Higuchi model.
