家禽霍亂菌苗用多殺性巴斯德桿菌之大量生產條件最適化及培養產物之抗原性評估(II)

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標題:	家禽霍亂菌苗用多殺性巴斯德桿菌之大量生產條件最適化及培養產物之抗原性評估(II) Optimizing Culture Condition for Pasteurella Multocida and Assessment of Fowl Cholera Bacteroid Vaccine Produced Thereof
作者:	邱淑媛
貢獻者:	保健營養系
關鍵字:	家禽霍亂巴斯德桿菌醱酵槽連續培養高密度培養 Fowl Cholera Pasteurella Fermentor Continuous culture High-density Culture
日期:	2006
上傳時間:	2008-11-21 10:35:11 (UTC+8)
出版者:	行政院農業委員會
摘要:	本研究擬以兩年時間完成三項主要工作： (1) 將93年度科技計畫中完成的多殺性巴斯德桿菌高密度液態培養平台放大製產業化層級， (2) 降低培養基成本， (3) 建立醱酵槽連續培養技術或高密度培養的技術。期能藉由提高菌液濃度、降低物料成本與引進醱酵程序自動控制的技術節約人力成本三方面，協助過內業者產製優質疫苗，提高疫苗產業的國際競爭力。 There are three aims of this study to be achieved in two years. (1) To scale up the high-density culture technique from the laboratory scale (which was developed for Pasteurella multocida with the financial supports from the Council of Agriculture, ROC in 2004) to a commercial scale, for better cell recovery than the commercially culture system being in use in vaccine production. (2) Lower the cost of culture medium by substituting certain of the components with fermentation-grade substrates. (3) To setup a continuous culture technique or a high-density culture technique in the fermenter with automatically feedback control by signals from the cultivation, to save the cost of manpower.
關聯:	計畫編號：95農科-6.1.5-檢-B2
显示于类别:	[保健營養系(所) ] 其他研究計畫

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