第三型與第二十八型基質金屬蛋白酶在南台灣口腔鳞狀細胞表皮癌中所扮演的角色

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標題:	第三型與第二十八型基質金屬蛋白酶在南台灣口腔鳞狀細胞表皮癌中所扮演的角色
作者:	林美惠
貢獻者:	生物科技系
日期:	2005
上傳時間:	2008-05-26 14:58:57 (UTC+8)
出版者:	台南縣：嘉南藥理科技大學生物科技系
摘要:	The newly identified MMP-28 has been shown to be expressed in several types of carcinomas, however, none of its functional role in transformation events is known. This study was to assess whether this proteinase plays a role in oral tumor malignancy. By using RT-PCR, we found that incidence of MMP-28 was significantly higher in 92 oral squamous cell carcinomas (OSCCs) (52/92, 56.5%) than in 7 oral premalignant lesions (OPMLs) (0/7, 0%) (P = 0.004). No statistically significant correlation was found between MMP-28 expression and tumor stage, thickness, size, and metastasis. Both mRNA and protein of MMP-28 were preferentially concentrated in OSCC specimens than in neighboring tissues as analyzed by semi-quantitative RT-PCR (P = 0.015) and immunohistochemistry, respectively. Transfection of an OSCC and an esophageal carcinoma cell lines with MMP-28 antisense oligodeoxynucleotide (AODN) resulted in the reduced secretion of MMP-28 protein and the ability of colony formation in soft agar without affecting cell growth. Our findings show the close correlation between MMP-28 and OSCC, and support a role for MMP- 28 in the anchorage-independent growth of both OSCC and esophageal carcinomas.
關聯:	計畫編號 : CNBT9405
显示于类别:	[生物科技系(所)] 校內計畫

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