Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/581
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/581


    Title: 幾丁聚醣-聚乙烯醇顆粒之製備及其在藥物釋放之應用
    Authors: 林彰泰
    劉夢春
    Contributors: 生活系
    Keywords: 幾丁聚醣
    聚乙烯醇
    交聯劑
    三聚磷酸鹽
    控制釋放
    Date: 2005
    Issue Date: 2008-05-26 14:03:59 (UTC+8)
    Publisher: 台南縣:嘉南藥理科技大學醫藥化學系
    Abstract: 幾丁聚醣具良好的生物相容性、吸收、分解特性,且低毒性又易於高溫高壓下滅菌,應用於生物醫藥材料。本實驗係利用幾丁聚醣—聚乙烯醇及交聯劑三聚磷酸鹽形成複合物顆粒,以製造控制釋放載體,並比較不同顆粒包覆阿斯匹靈之效果及其在控制釋放特性上的差異。研究發現TPP 交聯之幾丁聚醣—聚乙烯醇顆粒比無交聯之顆粒較能維持顆粒的完整性。且加入阿斯匹靈之幾丁聚醣與聚乙烯醇顆粒,都有粗糙表面,推測可能是阿斯匹靈妨礙聚乙烯醇與其他分子相互作用所致。
    Relation: 計畫編號 : CNAC9406
    Appears in Collections:[Dept. of Food & Drug Industry and Inspective Technology] Chna Project

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