Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by Triptolide, a diterpenoid isolated from the Chinese herb Tripterygium wilfordii

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Title:	Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by Triptolide, a diterpenoid isolated from the Chinese herb Tripterygium wilfordii 樟芝、雷公藤、薄葉牛皮消對乳癌細胞之增生抑制探討
Authors:	林美惠
Contributors:	生物科技系
Date:	2006
Issue Date:	2008-05-19 10:18:13 (UTC+8)
Publisher:	台南縣：嘉南藥理科技大學生物科技系
Abstract:	The Chinese medicinal herb Tripterygium wilfordii Hook and one of its active components triptolide, a diterpenoid triepoxide, have been shown to have anti-inflammatory, anti-fertility and anti-neoplastic activities. Recently, triptolide was shown to have antitumor properties by suppressing the growth and inducing apoptosis of a broad range of human tumor cells. To identity the anticancer mechanism of triptolide, we assayed its effect on apoptosis, cell cycle distribution. The results showed that triptolide induced apoptosis in MCF-7 cells, without affecting the cell cycle distribution. Our study reports here for the first time that the activity of the apoptotic induction may participate in the anti-proliferative activity of triptolide in MCF-7 cells.
Relation:	計畫編號 : CNBT9510
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Chna Project

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