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| 標題: | HER2 amplification in colorectal cancer with brain metastasis: A propensity score matching study |
| 作者: | Chen, Po-Chuan
Yeh, Yu-Min
Chu, Chun-Ting
Su, Pei-Fang
Chiu, Pin-Hsuan
Lin, Bo-Wen
Chen, Shang-Hung
Lin, Peng-Chan
Lee, Chung-Ta
Chen, Helen H. W.
Chen, Chien-Chin |
| 貢獻者: | Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg,Div Colorectal Surg
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Oncol
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Surg, Div Colorectal Surg
Natl Cheng Kung Univ, Dept Stat
Natl Cheng Kung Univ Hosp, Ctr Quantitat Sci, Clin Med Res Ctr
Natl Hlth Res Inst, Natl Inst Canc Res
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Genom Med
Natl Cheng Kung Univ, Coll Elect Engn & Comp Sci, Dept Comp Sci & Informat Engn
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Dept Biotechnol & Bioind Sci
Natl Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, PhD Program Translat Med |
| 關鍵字: | HER2 amplification
Colorectal cancer
Brain metastasis
Heterogeneity
Propensity score matching |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:05:50 (UTC+8) |
| 出版者: | ELSEVIER SCI LTD |
| 摘要: | Background: The association between human epidermal growth factor receptor -2 (HER2) amplification and brain metastasis (BM) in patients having colorectal cancer (CRC) has been suggested but not yet established. This study investigated the expression pat-terns of HER2, its association with BM, and its prognostic value in patients having CRC.Methods: We retrospectively identified 99 patients having metastatic CRC (mCRC) and BM (the BM cohort) and compared them with a cohort of 249 patients having mCRC and without BM (the stage IV cohort) by propensity score matching. Immunohistochemical studies of HER2 on all available paraffin-embedded tumour samples, either from the primary tumour, the metastasis (brain and/or extracranial sites) or both, were performed and analysed. HER2 fluorescent in situ hybridisation was applied when necessary. The expression of HER2 was compared and correlated with survival.Results: HER2 amplifications were detected in 16 (18.4%) of 87 and 9 (3.6%) of 249 patients who had specimens available in the BM and stage IV cohorts, respectively (P < .001). After propensity score matching, HER2 amplification was significantly associated with BM (odds ratio: 5.38, P = .003). HER2 heterogeneity was frequently observed not only at the single tumour level but also in paired tumour samples. A marginally significant longer survival since BM was found in patients having HER2-amplified mCRC than in those without (P = .07).Conclusions: HER2 amplification was significantly associated with BM in patients having mCRC and might have prognostic value for survival since BM. Given the heterogeneity of HER2 expression, the testing of HER2 status on available tissues from both primary and met-astatic tumours should be encouraged.(c) 2022 Elsevier Ltd. All rights reserved. |
| 關聯: | European Journal of Cancer, v.181 |
| 顯示於類別: | [行政單位] 456
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