SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients

doi:10.1097/MD.0000000000034426

Chia Nan University of Pharmacy & Science Institutional Repository > 行政單位 > 456 > Item 310902800/34930

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標題:	SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients
作者:	Chang, Shih-Lun Yang, Ching-Chieh Lai, Hong-Yue Tsai, Hsin-Hwa Yeh, Cheng-Fa Lee, Sung-Wei Kuo, Yu-Hsuan Kang, Nai-Wen Wu, Wen-Bin Chen, Tzu-Ju
貢獻者:	Chi Mei Med Ctr, Dept Otolaryngol Chung Hwa Univ Med Technol, Dept Med Technol Chi Mei Med Ctr, Dept Radiat Oncol Chia Nan Univ Pharm & Sci, Dept Pharm Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Trans Lab Precis Med China Med Univ, Coll Med, Sch Med, Dept Pharmacol China Med Univ Hosp, Dept Lab Med Chi Mei Med Ctr, Dept Internal Med Chi Mei Med Ctr, Dept Radiat Oncol Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol Chia Nan Univ, Coll Pharm & Sci Fu Jen Catholic Univ, Sch Med Fu Jen Catholic Univ, Grad Inst Biomed & Pharmaceut Sci, Coll Med Chi Mei Med Ctr, Dept Clin Pathol Natl Sun Yat Sen Univ, Inst Biomed Sci Chi Mei Med Ctr, Dept Clin Pathol
關鍵字:	cell adhesion-related genes nasopharyngeal carcinoma (NPC) SYNPO2
日期:	2023
上傳時間:	2024-12-25 11:05:49 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	Nasopharyngeal carcinoma (NPC) is the most common malignant neoplasm of the nasopharynx. Despite improvements in the clinical treatment strategies for NPC, NPC patients usually have poor survival rates because of late diagnosis, tumor metastasis, and recurrence. Therefore, the identification of potential diagnostic and prognostic markers for NPC is imperative. We investigated the differential expression of cell adhesion-related genes (gene ontology:0003779) and tumorigenesis-related genes (GSE12452) in patients with NPC. The correlations between synaptopodin-2 (SYNPO2) immune expression and clinicopathological features were analyzed using Pearson chi-square test. Multivariate analysis was performed using Cox proportional hazards model. SYNPO2 expression was significantly higher in NPC tumor tissues than in nontumor tissues. High SYNPO2 expression was significantly associated with the advanced disease stage (P = .006). Univariate analysis showed that high expression of SYNPO2 was associated with poor disease-specific survival, distal metastasis-free survival, and local recurrence-free survival in patients with NPC. Notably, our multivariate analysis demonstrated that high SYNPO2 expression was substantially correlated with inferior disease-specific survival (hazard ratio = 1.968, P = .012) and local recurrence-free survival (hazard ratio = 3.386, P = .001). Overall, our findings reveal that SYNPO2 may aid in the development of potential prognostic biomarkers for NPC patients.
關聯:	Medicine, v.102, n.30
顯示於類別:	[行政單位] 456

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