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| 標題: | SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients |
| 作者: | Chang, Shih-Lun
Yang, Ching-Chieh
Lai, Hong-Yue
Tsai, Hsin-Hwa
Yeh, Cheng-Fa
Lee, Sung-Wei
Kuo, Yu-Hsuan
Kang, Nai-Wen
Wu, Wen-Bin
Chen, Tzu-Ju |
| 貢獻者: | Chi Mei Med Ctr, Dept Otolaryngol
Chung Hwa Univ Med Technol, Dept Med Technol
Chi Mei Med Ctr, Dept Radiat Oncol
Chia Nan Univ Pharm & Sci, Dept Pharm
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Trans Lab Precis Med
China Med Univ, Coll Med, Sch Med, Dept Pharmacol
China Med Univ Hosp, Dept Lab Med
Chi Mei Med Ctr, Dept Internal Med
Chi Mei Med Ctr, Dept Radiat Oncol
Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol
Chia Nan Univ, Coll Pharm & Sci
Fu Jen Catholic Univ, Sch Med
Fu Jen Catholic Univ, Grad Inst Biomed & Pharmaceut Sci, Coll Med
Chi Mei Med Ctr, Dept Clin Pathol
Natl Sun Yat Sen Univ, Inst Biomed Sci
Chi Mei Med Ctr, Dept Clin Pathol |
| 關鍵字: | cell adhesion-related genes
nasopharyngeal carcinoma (NPC)
SYNPO2 |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:05:49 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Nasopharyngeal carcinoma (NPC) is the most common malignant neoplasm of the nasopharynx. Despite improvements in the clinical treatment strategies for NPC, NPC patients usually have poor survival rates because of late diagnosis, tumor metastasis, and recurrence. Therefore, the identification of potential diagnostic and prognostic markers for NPC is imperative. We investigated the differential expression of cell adhesion-related genes (gene ontology:0003779) and tumorigenesis-related genes (GSE12452) in patients with NPC. The correlations between synaptopodin-2 (SYNPO2) immune expression and clinicopathological features were analyzed using Pearson chi-square test. Multivariate analysis was performed using Cox proportional hazards model. SYNPO2 expression was significantly higher in NPC tumor tissues than in nontumor tissues. High SYNPO2 expression was significantly associated with the advanced disease stage (P = .006). Univariate analysis showed that high expression of SYNPO2 was associated with poor disease-specific survival, distal metastasis-free survival, and local recurrence-free survival in patients with NPC. Notably, our multivariate analysis demonstrated that high SYNPO2 expression was substantially correlated with inferior disease-specific survival (hazard ratio = 1.968, P = .012) and local recurrence-free survival (hazard ratio = 3.386, P = .001). Overall, our findings reveal that SYNPO2 may aid in the development of potential prognostic biomarkers for NPC patients. |
| 關聯: | Medicine, v.102, n.30 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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