Therapeutic Effect of Human Adipocyte-derived Stem Cell-derived Exosomes on a Transgenic Mouse Model of Parkinson's Disease

doi:10.21873/invivo.13300

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Title:	Therapeutic Effect of Human Adipocyte-derived Stem Cell-derived Exosomes on a Transgenic Mouse Model of Parkinson's Disease
Authors:	Chan, Lung Hsu, Wayne Chen, Kai-yun Wang, Weu Hung, Yi-chieh Hong, Chien-tai
Contributors:	Taipei Med Univ, Shuang Ho Hosp, Dept Neurol Taipei Med Univ, Coll Med, Sch Med, Dept Neurol Taipei Med Univ, Taipei Neurosci Inst Taipei Med Univ Hosp, Dept Surg, Div Gen Surg Taipei Med Univ, Coll Med Sci & Technol, PhD Program Med Neurosci Taipei Med Univ, Coll Med, Sch Med, Dept Surg Chi Mei Med Ctr, Dept Neurosurg Chia Nan Univ Pharm & Sci, Dept Recreat & Healthcare Management Chi Mei Med Ctr, Dept Neurosurg, Dept Surg Taipei Med Univ, Shuang Ho Hosp, Dept Neurol
Keywords:	Parkinson's disease adipocyte-derived stem cells exosome inflammation
Date:	2023
Issue Date:	2024-12-25 11:05:42 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	Background/Aim: Stem cell therapy and regenerative medicine are promising for treating Parkinson's disease (PD) not only for the potential for cell replacement but also for the paracrine effect of stem cell secretion, especially proteins and nucleotide-enriched exosomes. This study investigated the neuroprotective effect of exosomes secreted from human adipocyte-derived stem cells (hADSCs) on PD. Materials and Methods: hADSCs were isolated from the visceral fat tissue of individuals without PD who underwent bariatric surgery and were validated using surface markers and differentiation ability.
Relation:	In Vivo, v.37, n.5, pp.2028-2038
Appears in Collections:	[Offices] 456

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