Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel?: double-blind, placebo-controlled trial

doi:10.1016/j.fshw.2023.02.043

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34919

Title:	Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel?: double-blind, placebo-controlled trial
Authors:	Liang, Chia-Hua Lin, Yung -Hsiang Lin, Yung -Kai Chiang, Chi -Fu
Contributors:	Chia Nan Univ Pharm & Sci, Inst Cosmet Sci, Dept Cosmet Sci TCI CO Ltd, Res & Design Ctr Taiwan Ocean Univ, Inst Food Safety & Risk Management, Dept Food Sci Chung Hsing Univ, Grad Inst Biomed Engn
Keywords:	Banana flower Dihydrotestosterone Hair loss ROS Follicle dermal papilla cells
Date:	2023
Issue Date:	2024-12-25 11:05:39 (UTC+8)
Publisher:	TSINGHUA UNIV PRESS
Abstract:	Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract (HappyAngel (R)) was used to treat human hair follicle dermal papilla cells (HFDPCs) and the expression of reactive oxygen species (ROS), dihydrotestosterone (DHT), and hair-related genes (SRD5A1, SRD5A2, AR, and KROX20) were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract (HappyAngel (R)) can stimulate hair growth and inhibit the activation of hair loss genes.(c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Relation:	Food Science And Human Wellness, v.12, n.5, pp.1917-1923
Appears in Collections:	[Offices] 456

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