The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma

doi:10.4103/ds.DS-D-22-00103

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標題:	The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma
作者:	Li, Shu-Hao Chiou, Chien-Chun Chen, Chien-Chin
貢獻者:	Chang Gung Mem Hosp Linkou Branch, Dept Dermatol Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Dermatol Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Natl Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, PhD Program Translat Med Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Dept Biotechnol & Bioind Sci
關鍵字:	Dermatology epigenetic histone mucinous carcinoma skin trimethylation of histone h3 at lysine 27
日期:	2023
上傳時間:	2024-12-25 11:05:05 (UTC+8)
出版者:	WOLTERS KLUWER MEDKNOW PUBLICATIONS
摘要:	Primary cutaneous mucinous carcinoma (PCMC) is rare, and its carcinogenesis is unclear. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a key regulator in chromatin remodeling-controlled transcription. Focusing on the epigenetic mechanism, we aimed to investigate the expression of H3K27me3 in PCMC by immunohistochemistry. A retrospective cohort of PCMC patients from a tertiary hospital in Taiwan was enrolled to evaluate the clinicopathologic features, treatment outcome, and protein expression. Immunohistochemistry for H3K27me3 was performed on all PCMCs and a comparison group of colonic mucinous adenocarcinoma and pure mucinous carcinoma of the breast. The percentage of H3K27me3-negative tumor cells was calculated and analyzed. Three patients with PCMC were recruited. All PCMCs were solitary and slow growing, arising from the head-and-neck region. All PCMCs had tumor excision without local recurrence or metastasis. The loss of H3K27me3 expression was significant in PCMCs (mean & PLUSMN; standard deviation [SD]: 21.0% & PLUSMN; 6.6%) compared to other mucinous carcinomas (mean & PLUSMN; SD: 3.8% & PLUSMN; 1.7%) (P = 0.019). In conclusion, we report a reduction in H3K27me3 expression in PCMC. In contrast, H3K27me3 expression is retained or mildly reduced in other mucinous carcinomas. This is the first study to indicate a possible role of epigenetic events in the pathobiology of PCMC.
關聯:	Dermatologica Sinica, v.41, n.2, pp.116-120
显示于类别:	[行政單位] 456

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