Effects of perioperative magnesium on postoperative analgesia following thoracic surgery: a meta-analysis of randomised controlled trials

doi:10.1684/mrh.2024.0522

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Title:	Effects of perioperative magnesium on postoperative analgesia following thoracic surgery: a meta-analysis of randomised controlled trials
Authors:	Hung, Kuo-Chuan Yang, Sheng-Hsiang Liao, Shu-Wei Yu, Chia-Hung Liu, Mei-Yuan Chen, Jen-Yin
Contributors:	Natl Sun Yat Sen Univ, Sch Med Chi Mei Med Ctr, Dept Anesthesiol Chi Mei Med Ctr, Dept Neurol Chia Nan Univ Pharm & Sci Southern Taiwan Univ Sci & Technol, Ctr Gen Educ Chi Mei Med Ctr, Dept Nutr Chung Hwa Univ Med Technol, Dept Food Nutr
Keywords:	Perioperative magnesium thoracic surgery postoperative pain
Date:	2023
Issue Date:	2024-12-25 11:05:02 (UTC+8)
Publisher:	JLE
Abstract:	Objectives: To evaluate the analgesic effects of intravenous magnesium in patients undergoing thoracic surgery. Methods: Randomised clinical trials (RCTs) were systematically identified from MEDLINE, EMBASE, Google Scholar and the Cochrane Library from inception to May 1st, 2023. The primary outcome was the effect of intravenous magnesium on the severity of postoperative pain at 24 hours following surgery, while the secondary outcomes included association between intravenous magnesium and pain severity at other time points, morphine consumption, and haemodynamic changes. Results: Meta-analysis of seven RCTs published between 2007 and 2019, involving 549 adults, showed no correlation between magnesium and pain scores at 1-4 (standardized mean difference [SMD]=-0.06; p=0.58), 8-12 (SMD=-0.09; p=0.58), 24 (SMD=-0.16; p=0.42), and 48 (SMD=-0.27; p=0.09) hours post-surgery. Perioperative magnesium resulted in lower equivalent morphine consumption at 24 hours post-surgery (mean difference [MD]=-25.22 mg; p=0.04) and no effect at 48 hours (MD=-4.46 mg; p=0.19). Magnesium decreased heart rate (MD = -5.31 beats/min; p=0.0002) after tracheal intubation or after surgery, but had no effect on postoperative blood pressure (MD=-6.25 mmHg; p=0.11). There was a significantly higher concentration of magnesium in the magnesium group compared with that in the placebo group (MD = 0.91 mg/dL; p<0.00001). Conclusion: This meta-analysis provides evidence supporting perioperative magnesium as an analgesic adjuvant at 24 hours following thoracic surgery, but no opioid-sparing effect at 48 hours post
Relation:	Magnesium Research, v.36, n.4, pp.54-68
Appears in Collections:	[Offices] 456

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